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Pestigon Spot-On Solution for Cats

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Clear, colourless to pale yellow solution for topical application to the skin.
Pestigon 50 mg spot-on solution for cats contains 50 mg fipronil per 0.50 ml pipette.


For the treatment and prevention of flea infestations (Ctenocephalides felis.) and ticks (Dermacentor reticulates) in dogs and cats.
Pestigon has a persistent acaricidal efficacy against the tick Dermacentor reticulatus for up to 2 weeks in cats, and for up to 2 weeks against Ixodes ricinus, up to 3 weeks against Rhipicephalus sanguineus, and up to 4 weeks against Dermacentor reticulatus in dogs.
Insecticidal efficacy against new infestations by adult fleas for up to 8 weeks in dogs and up to 5 weeks in cats.
The product can be used as part of a treatment strategy for the control of Flea Allergy Dermatitis (FAD) in both cats and dogs, where this has been previously diagnosed by a veterinary surgeon.
If ticks are attached when the product is applied, all ticks will not be killed within the first 48 hours but they may be killed within a week.

Dosage & Administration

Only by topical application to the skin.
- Pestigon 50mg spot-on solution for cats (approx 7.5-15mg/ kg): 1 pipette of 0.50 ml

Method of Administration:
Hold upright. Tap the narrow part of the pipette to ensure the contents are within the main body of the pipette. Break back the snap-off top from the spot-on pipette along the scored line. Part the coat between the shoulder blades until the skin is visible. Place the tip of the pipette on the skin and squeeze gently at one or two spots to empty its contents onto the skin.

It is important to make sure that the product is applied to an area where the animal cannot lick it off, and to make sure that the animals do not lick each other following treatment.

Care should be taken to avoid excessive wetting of the hair with the product since this will cause a sticky appearance of hairs at the treatment spot.
However, should this occur, it will disappear within 24 hours post application.
In the absence of safety studies, the minimum treatment interval is 4 weeks.
For the optimal control of infestation by flea and or/tick the treatment schedule can be based on local epidemiological situation.

Contraindictions, Warnings etc

Do not use in cats weighing less than 1kg.
In the absence of available data, the veterinary medicinal product should not be used on kittens less than 8 weeks old.
Do not use on sick (systemic disease, fever, etc.) or convalescent animals.
Do not use on rabbits, as adverse drug reactions and even death could occur.
Do not use in cases of known hypersensitivity to the active or to any of the excipients.
Animals should be weighed accurately prior to treatment.
Avoid contact with the animal's eyes. In the case of accidental eye contact immediately and thoroughly flush the eyes with water.
Do not apply the product on wounds or damaged skin.
Specific studies investigating the safety of the product following repeated administration or at overdosage have not been conducted due to the known safety profile of the active substance and excipients.

Special warnings for each target species
The product does not prevent ticks from attaching to the animals, but ticks may be killed in the first 24-48 hours after attachment prior to a full engorgement and therefore minimising the risk of transmission of diseases. Once dead, ticks will drop off the animal, but any remaining ticks may easily be removed by a gentle pull.
For the optimal control of flea infestation in a multi-pet household, all dogs and cats in the house should be treated with a suitable insecticide.
There may be an attachment of ticks. For this reason transmission of infectious diseases cannot be completely excluded if conditions are unfavourable. Fleas from pets often infest the animal’s basket, bedding and regular resting areas such as carpets and soft furnishings which should be treated, in case of massive infestation and at the beginning of the control measures, with a suitable insecticide and vacuumed regularly.

No data on the effect of bathing/shampooing on the efficacy of the product in cats are available.

Adverse reactions
If licking occurs, a brief period of hypersalivation may be observed due mainly to the nature of the carrier.
Among the extremely rare suspected adverse reactions, transient cutaneous reactions at the application site (skin discoloration, local alopecia, pruritus, erythema) and general pruritus or alopecia have been reported after use.
Exceptionally, hypersalivation, reversible neurological signs (hyperaesthesia, depression, nervous signs), vomiting or respiratory signs have been observed after use.

Use During Pregnancy, Lactation or Lay
Laboratory studies using fipronil have not produced any evidence of a teratogenic or foetotoxic effects.

No studies have been carried out in pregnant or lactating cats using this veterinary medicinal product, therefore use during pregnancy/ lactation should only occur after a relevant benefit-risk analysis made by the treating veterinarian.

The toxicity of the product administered to the skin is very low. The risk of experiencing adverse effects may however increase when overdosing, so animals should always be treated with the correct pipette size according to bodyweight.

Operator Warnings:
This product can cause mucous membrane and eye irritation. Therefore, contact of the product with the mouth and eyes should be avoided.

In cases of accidental eye contact, immediately and thoroughly rinse the eye with plain water. If eye irritation persists seek medical advice and show the package leaflet or the label to a physician.

People with a known hypersensitivity to fipronil or excipients should avoid contact with the veterinary product.

Avoid contents coming into contact with the fingers. If this occurs, wash hands with soap and water.

Wash hands after use. Do not smoke, drink or eat during application.

Treated animals should not be handled until this application site is dry, and children should not be allowed to play with treated animals until the application site is dry. It is therefore recommended that animals are not treated during the day, but should be treated during the early evening, and that recently treated animals should not be allowed to sleep with owners, especially children.

Pharmaceutical Precautions

This medicinal product does not require any special temperature storage conditions.
Store in original container in order to protect from light and moisture.
Keep out of reach and sight of children. For animal treatment only.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

The product should not enter water courses as this may be dangerous for fish and other aquatic organisms. Do not contaminate ponds, waterways or ditches with the product or empty containers.

Further Information

Pharmacodynamic properties
Fipronil is an insecticide/acaricide in the phenylpyrazole family. It acts by inhibiting the GABA complex, binding to the chloride channel and thereby blocking pre- and post-synaptic transfer of chloride ions across the cell membrane. This results in uncontrolled activity of the central nervous system and death in insects and acarids.

Newly arriving fleas are killed within 24 hours of landing on the animal. Ticks if already present at the time of application of the product, may not always be killed in the first 48 hours, however will be killed within 9 days post treatment.

Pharmacokinetic Particulars
After a local application of fipronil to the cat, systemic absorption is negligible.

The concentrations of fipronil on the hair decrease with time.

Fipronil is mainly metabolised to its sulfone derivative (RM1602), which also possesses insecticidal and acaricidal properties.
The concentrations of fipronil on the hair decrease with time.

The product is effective against flea infestation (Ctenocephalides felis) for approximately 37days and against tick infestations for 21 days, depending on the tick species and the level of challenge.

Click here to read the SPC for 50mg Pestigon Spot on for Cats

Please note: Product information presented on this website is intended only as a brief summary of Norbrook products for your convenience. Not all products or indications are licensed in every country and may be subject to further local variations. For specific product information you should always consult a healthcare professional from your region. Please see our terms and conditions for further information.

If you are a veterinary surgeon and would like additional information on any of our products please email enquiries@norbrook.co.uk