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Pestigon Spot-On Solution for Dogs

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Presentation


Clear, colourless to pale yellow solution for topical application to the skin.
Pestigon 67 mg spot-on solution for small dogs (2 - 10 kg) contains 67 mg fipronil per 0.67 ml pipette.
Pestigon 134 mg spot-on solution for medium dogs (10 - 20 kg) contains 134 mg fipronil per 1.34 ml pipette.
Pestigon 268 mg spot-on solution for large dogs (20 - 40 kg) contains 268 mg fipronil per 2.68 ml pipette.
Pestigon 402 mg spot-on solution for very large dogs (40 - 60 kg) contains 402 mg fipronil per 4.02 ml pipette.

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Uses


For the treatment and prevention of flea infestations (Ctenocephalides felis.) and ticks (Dermacentor reticulates) in dogs and cats.
Pestigon has a persistent acaricidal efficacy against the tick Dermacentor reticulatus for up to 2 weeks in cats, and for up to 2 weeks against Ixodes ricinus, up to 3 weeks against Rhipicephalus sanguineus, and up to 4 weeks against Dermacentor reticulatus in dogs.
Insecticidal efficacy against new infestations by adult fleas for up to 8 weeks in dogs and up to 5 weeks in cats.
The product can be used as part of a treatment strategy for the control of Flea Allergy Dermatitis (FAD) in both cats and dogs, where this has been previously diagnosed by a veterinary surgeon.
If ticks are attached when the product is applied, all ticks will not be killed within the first 48 hours but they may be killed within a week.

Dosage & Administration


Only by topical application to the skin.
- Pestigon 67 mg spot-on solution for small dogs (2 - 10 kg): 1 pipette of 0.67 ml is sufficient for the treatment of a dog with a body weight of 2 kg up to 10 kg corresponding to a recommended minimum dose of 6.7 mg fipronil/kg body weight.
- Pestigon 134 mg spot-on solution for medium dogs (10 - 20 kg): 1 pipette of 1.34 ml is sufficient for the treatment of a dog with a body weight of 10 kg up to 20 kg corresponding to a recommended minimum dose of 6.7 mg fipronil/kg body weight.
- Pestigon 268 mg spot-on solution for large dogs (20 - 40 kg): 1 pipette of 2.68 ml is sufficient for the treatment of a dog with a body weight of 20 kg up to 40 kg corresponding to a recommended minimum dose of 6.7 mg fipronil/kg body weight.
- Pestigon 402 mg spot-on solution for very large dogs (40 - 60 kg): 1 pipette of 4.02 ml is sufficient for the treatment of a dog with a body weight of 40 kg up to 60 kg corresponding to a recommended minimum dose of 6.7 mg fipronil/kg body weight.
For dogs over 60 kg: use two 2.68 ml pipettes (Pestigon for large dogs)

Method of Administration:
Hold upright. Tap the narrow part of the pipette to ensure the contents are within the main body of the pipette. Break back the snap-off top from the spot-on pipette along the scored line. Part the coat between the shoulder blades until the skin is visible. Place the tip of the pipette on the skin and squeeze gently at one or two spots to empty its contents onto the skin.

It is important to make sure that the product is applied to an area where the animal cannot lick it off, and to make sure that the animals do not lick each other following treatment.

Care should be taken to avoid excessive wetting of the hair with the product since this will cause a sticky appearance of hairs at the treatment spot.
However, should this occur, it will disappear within 48 hours post application.
In the absence of safety studies, the minimum treatment interval is 4 weeks.
For the optimal control of infestation by flea and or/tick the treatment schedule can be based on local epidemiological situation.

Contraindictions, Warnings etc


Do not use in dogs weighing less than 2kg.
In the absence of available data, the veterinary medicinal product should not be used on puppies less than 8 weeks old.
Do not use on sick (systemic disease, fever, etc.) or convalescent animals.
Do not use on rabbits, as adverse drug reactions and even death could occur.
This product has been specifically developed for dogs. Do not use in cats, as this could lead to overdosing.
Do not use in cases of known hypersensitivity to the active or to any of the excipients.
Animals should be weighed accurately prior to treatment.
Pestigon 134 mg spot-on solution for medium dogs should not be used on dogs weighing less than 10 kg.
Pestigon 268 mg spot-on solution for large dogs should not be used on dogs weighing less than 20 kg.
Pestigon 402 mg spot-on solution for very large dogs should not be used on dogs weighing less than 40 kg.
Avoid contact with the animal's eyes. In the case of accidental eye contact immediately and thoroughly flush the eyes with water.
Do not apply the product on wounds or damaged skin.
Specific studies investigating the safety of the product following repeated administration or at overdosage have not been conducted due to the known safety profile of the active substance and excipients.

Special warnings for each target species
The product does not prevent ticks from attaching to the animals, but ticks may be killed in the first 24-48 hours after attachment prior to a full engorgement and therefore minimising the risk of transmission of diseases. Once dead, ticks will drop off the animal, but any remaining ticks may easily be removed by a gentle pull.
For the optimal control of flea infestation in a multi-pet household, all dogs and cats in the house should be treated with a suitable insecticide.
There may be an attachment of ticks. For this reason transmission of infectious diseases cannot be completely excluded if conditions are unfavourable. Fleas from pets often infest the animal’s basket, bedding and regular resting areas such as carpets and soft furnishings which should be treated, in case of massive infestation and at the beginning of the control measures, with a suitable insecticide and vacuumed regularly.

Avoid frequent swimming or shampooing of the animal because the maintenance of effectiveness of the product in these cases has not been tested.

Adverse reactions
If licking occurs, a brief period of hypersalivation may be observed due mainly to the nature of the carrier.
Among the extremely rare suspected adverse reactions, transient cutaneous reactions at the application site (skin discoloration, local alopecia, pruritus, erythema) and general pruritus or alopecia have been reported after use.
Exceptionally, hypersalivation, reversible neurological signs (hyperaesthesia, depression, nervous signs), vomiting or respiratory signs have been observed after use.

Use During Pregnancy, Lactation or Lay
Laboratory studies using fipronil have not produced any evidence of a teratogenic or foetotoxic effects.

In the absence of studies to evaluate the safety of this product in pregnant or lactating animals use only according to the benefit/risk assessment by the responsible veterinarian.

Overdose
No adverse effects were observed in target animal safety studies in 8 week old puppies, growing dogs and dogs weighing circa 2kg treated on 3 occasions at five times the recommended dose. The risk of experiencing adverse effects may however increase when overdosing, so animals should always be treated with the correct pipette size according to bodyweight.

Operator Warnings:
This product can cause mucous membrane and eye irritation. Therefore, contact of the product with the mouth and eyes should be avoided.

In cases of accidental eye contact, immediately and thoroughly rinse the eye with plain water. If eye irritation persists seek medical advice and show the package leaflet or the label to a physician.

People with a known hypersensitivity to fipronil or excipients should avoid contact with the veterinary product.

Avoid contents coming into contact with the fingers. If this occurs, wash hands with soap and water.

Wash hands after use. Do not smoke, drink or eat during application.

Treated animals should not be handled until this application site is dry, and children should not be allowed to play with treated animals until the application site is dry. It is therefore recommended that animals are not treated during the day, but should be treated during the early evening, and that recently treated animals should not be allowed to sleep with owners, especially children.

Pharmaceutical Precautions


This medicinal product does not require any special temperature storage conditions.
Store in original container in order to protect from light and moisture.
Keep out of reach and sight of children. For animal treatment only.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

The product should not enter water courses as this may be dangerous for fish and other aquatic organisms. Do not contaminate ponds, waterways or ditches with the product or empty containers.

Further Information


Pharmacodynamic properties
Fipronil is an insecticide/acaricide in the phenylpyrazole family. It acts by inhibiting the GABA complex, binding to the chloride channel and thereby blocking pre- and post-synaptic transfer of chloride ions across the cell membrane. This results in uncontrolled activity of the central nervous system and death in insects and acarids.

Newly arriving fleas are killed within 24 hours of landing on the animal. Ticks if already present at the time of application of the product, may not always be killed in the first 48 hours, however will be killed within 9 days post treatment.

The product is effective against flea infestation (Ctenocephalides felis) for approximately 8 weeks and against tick infestations for up to 4 weeks (see indications for use), depending on the tick species and the level of challenge.

Click here to read the SPC for 67mg for small dogs.
Click here to read the SPC for 134mg for medium dogs
Click here to read the SPC for 268mg for large dogs
Click here to read the SPC for 402mg for very large dogs

Please note: Product information presented on this website is intended only as a brief summary of Norbrook products for your convenience. Not all products or indications are licensed in every country and may be subject to further local variations. For specific product information you should always consult a healthcare professional from your region. Please see our terms and conditions for further information.

If you are a veterinary surgeon and would like additional information on any of our products please email enquiries@norbrook.co.uk