() Cefenil® RTU (ceftiofur hydrochloride sterile suspension) | Norbrook

Cefenil® RTU  

(ceftiofur hydrochloride sterile suspension)

Broad-spectrum Cefenil® RTU is the industry's first generic, ready-to-use, veterinary prescription, ceftiofur hydrochloride injectable that is easier to syringe than Excenel® RTU EZ (ceftiofur hydrochloride) Sterile Suspension1

Target Species: Beef cattle, Dairy cattle, Swine

Product Attributes

  • Broad-spectrum cephalosporin antibiotic

  • Ready-to-use formulation

  • FDA approved

  • Available in 100 mL and 250 mL vials


  • Treats bovine respiratory disease (BRD)

  • Treats foot rot and acute metritis

  • Three-day meat withdrawal in cattle

  • Fits existing protocols:

         - Treats lactating dairy cows with zero milk discard

         - Treatment timing coincides with fresh cow evaluations


  • Treats swine respiratory disease (SRD)

  • Four-day withdrawal in swine. Among the shortest withdrawal times in the swine industry.

  • Cefenil® RTU effectively treats disease with no changes to  existing protocols 


CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Federal law prohibits extra-label use of this drug in cattle and swine for disease prevention purposes; at unapproved doses, frequencies, durations, or routes of administration; and in unapproved major food producing species/production classes.



Observe label directions and withdrawal times. Not for use in calves to be processed for veal. As with all drugs, the use of Cefenil® RTU (ceftiofur hydrochloride sterile suspension) is contraindicated in animals previously found to be hypersensitive to the drug. See product labeling for full product information.

1Reference on file.

  • Active Ingredient(s)

    ceftiofur hydrochloride

  • Dosage Form

    Ready-to-use sterile suspension

  • Indications

    Swine: CEFENIL® RTU is indicated for treatment/control of swine bacterial respiratory disease (swine bacterial pneumonia) associated with Actinobacillus (Haemophilus) pleuropneumoniae, Pasteurella multocida, Salmonella choleraesuis and Streptococcus suis.

    Cattle: CEFENIL® RTU is indicated for treatment of the following bacterial diseases:

    - Bovine respiratory disease (BRD, shipping fever, pneumonia) associated with Mannheimia haemolytica, Pasteurella multocida and Histophilus  somni.

    - Acute bovine interdigital necrobacillosis (foot rot, pododermatitis) associated with Fusobacterium necrophorum and Bacteroides melaninogenicus.

     - Acute metritis (0 to 14 days post-partum) associated with bacterial organisms susceptible to ceftiofur

  • Dosage and Administration

    Shake for 90 seconds to ensure complete resuspension before using.
    Swine: Administer intramuscularly at a dosage of 1.36 to 2.27 mg ceftiofur equivalents/lb (3.0 to 5.0 mg/kg) BW (1 mL of sterile suspension per 22 to 37 lb BW). Treatment should be repeated at 24 h intervals for a total of three consecutive days.
    Cattle: - For bovine respiratory disease and acute bovine interdigital necrobacillosis: administer by intramuscular or subcutaneous administration at the dosage of 0.5 to 1.0 mg ceftiofur equivalents/lb (1.1 to 2.2 mg/kg) BW (1 to 2 mL sterile suspension per 100 lb BW). Administer daily at 24 h intervals for a total of three consecutive days. Additional treatments may be administered on Days 4 and 5 for animals which do not show a satisfactory response (not recovered) after the initial three treatments. In addition, for BRD only, administer intramuscularly or subcutaneously 1.0 mg ceftiofur equivalents/lb (2.2 mg/kg) BW every other day on Days 1 and 3 (48 h interval). Do not inject more than 15 mL per injection site. Selection of dosage level (0.5 to 1.0 mg/lb) and regimen/duration (daily or every other day for BRD only) should be based on an assessment of the severity of disease, pathogen susceptibility and clinical response. 
    - For acute post-partum metritis: administer by intramuscular or subcutaneous administration at the dosage of 1.0 mg ceftiofur equivalents/lb (2.2 mg/kg) BW (2 mL sterile suspension per 100 lb BW). 
    Administer at 24 h intervals for five consecutive days. Do not inject more than 15 mL per injection site.

    Cefenil RTU Residue Warning

  • Storage

    Do not store above 30°C (86°F). Shake well before using. Protect from freezing. Contents should be used within 42 days after the first dose is removed.

A Comprehensive Antibiotic Portfolio

Norbrook® now covers five classes of antibiotics.

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Please note: Product information presented on this website is intended only as a brief summary of Norbrook products for your convenience. Not all products or indications are licensed in every country and may be subject to further local variations. For specific product information you should always consult a healthcare professional from your region or visit the local government agency website for the most up to date information. Please see our terms and conditions for further information.